DO NOT PLACE IN THE MEDICAL RECORD
Developed by the Acute Liver Failure Study Group
Published in PLoS ONE
A checklist for experienced providers to help manage patients with acute liver failure in the ICU
Completed:
| Drug / toxin | Obtain 6-month medication/toxin/ingestion history including OTC supplements, herbals, wild mushrooms, weight loss drugs Urine and serum toxicology screens Acetaminophen level |
|---|---|
| Viral | Anti-HAV IgM HBsAg, anti-HBc IgM, HBV DNA (quantitative) Anti-HCV, HCV RNA |
| Autoimmune | Antinuclear antibody Anti-smooth muscle antibody/anti-actin antibody Immunoglobulin G |
| Vascular / Budd-Chiari / Ischemia | Abdominal ultrasound with Doppler |
| Wilson | Check for hemolytic anemia (high indirect bilirubin), low alkaline phosphatase, renal failure, acidosis |
| Viral | Anti-HEV HSV DNA EBV DNA CMV DNA Anti-HDV/HDV RNA |
|---|---|
| Autoimmune | Anti-liver/kidney microsomal antibody Liver biopsy |
| Vascular / Budd Chiari / Ischemia | CT/MRI Assess for hypercoagulable state including search for malignancy Interventional radiology consultation Echocardiography/ECG |
| Wilson | Ceruloplasmin 24-hour urine for copper Serum copper Ophthalmology consultation to look for Kayser-Fleischer rings |
| Acute Fatty Liver of Pregnancy / HELLP | β-HCG Obstetrics consultation |
| Malignancy | CT/MRI Liver biopsy |
| Indeterminate | Liver biopsy |
| Acetaminophen toxicity | N-acetylcysteine (NAC) |
|---|---|
| Mushroom poisoning | Charcoal, NAC, penicillin G and/or silibinin |
| HBV | Entecavir |
| HSV | Acyclovir |
| Autoimmune | Corticosteroids |
| Budd Chiari | Anticoagulation, TIPS |
| Wilson | Consider early CRRT |
| Acute Fatty Liver of Pregnancy / HELLP | Early delivery |